Gossypol Acetic Acid as a Reference Standard in the Determination of Gossypol
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چکیده
منابع مشابه
Gossypol acetic acid induces apoptosis in RAW264.7 cells via a caspase-dependent mitochondrial signaling pathway
To investigate the effects of gossypol acetic acid (GA) on proliferation and apoptosis of the macrophage cell line RAW264.7 and further understand the possible underlying mechanism responsible for GA-induced cell apoptosis, RAW264.7 cells were treated with GA (25~35 μmol/L) for 24 h and the cytotoxicity was determined by MTT assay, while apoptotic cells were identified by TUNEL assay, acridine ...
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Based on the previous observations that gossypol is biosynthetically formed from acetate, and from the location of the incorporated 1% atoms, gossypol biosynthesis via the isoprenoid pathway has been postulated. To support this hypothesis, the incorporation of mevalonate-2J4C (a key intermediate in the isoprenoid pathway) into gossypol as well as the distribution of the radioactivity in the gos...
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Since our previous publication (17) on this subject, several articles have appeared in which other explanations of cottonseed-meal poisoning have been offered. Thus, Rommel and Vedder (14) have suggested that poisoning by cottonseed meal is similar to beriberi, and is caused by deficient diets. This view was based on the similarity of post-mortem symptoms noted in pigs fed on rice and tankage. ...
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Gossypol, a polyphenolic binaphthalene -dialdehyde reputed to exert contraceptive action in males, reversibly inhibits adenylate cyclase [ATP pyrophosphate lyase (cyclizing), EC 4.6.1.1] in a concentration-dependent manner. In membranes prepared from a variety of organs, the half-maximal inhibitory concentration (IC50) ranges from 75 microM (rat Leydig tumor cells) to 250 microM (rat liver memb...
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Gossypol is a phenolic compound produced by pigment glands in cotton stems, leaves, seeds, and flower buds (Gossypium spp.). Cottonseed meal is a by-product of cotton that is used for animal feeding because it is rich in oil and proteins. However, gossypol toxicity limits cottonseed use in animal feed. High concentrations of free gossypol may be responsible for acute clinical signs of gossypol ...
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ژورنال
عنوان ژورنال: Journal of AOAC INTERNATIONAL
سال: 1960
ISSN: 0095-9111
DOI: 10.1093/jaoac/43.2.329